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KMID : 0383819910380030228
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Tuberculosis and Respiratory Diseases
1991 Volume.38 No. 3 p.228 ~ p.235
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Gene Expression of Surfactant-Associated Proteins
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박성수/Sung Soo Park
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Abstract
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Pulmonary surfactant is a lipoprotein complex composed primarily of phospholipid and
lungspecific apoproteins that reduces surface tension in the alveolus and maintains
alveolar stability at low lung volume. Three families of lung-specific apoproteins have
been described: SP-A, a glycoprotein with a reduced molecular weight of 28∼36 KDa,
SP-B a hydrophobic protein with a nonreduced molecular weight of 18 KDa, and SP-C
a hydrophobic protein with a non-reduced molecular weight of 5∼8 KDa.
Surfactant proteins have important roles in regulating surfactant metabolism as well
as in determining its physical properties.
The synthesis of the active surfactant peptides appears to be modulated by system
with considerable complexity, including numerous levels of regulation such as
cell-specific, hormonal and developmental controls.
Endotoxin appears to alter surfactant protein mRNAs differentially.
It is hoped that the elucidation of the factors controlling the synthesis and metabolism
of the surfactant proteins will aid in understanding the pathogenesis of hyaline
membrane disease and offer new avenues for the therapy and diagnosis of ther
pulmonary disorders as well.
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